A section of Kingston Road was closed down in both directions west of Markham Road, after what police are calling a multi vehicle crash.
As many as 6 cars and a tractor trailer all collided near Bellamy, just before 10:30 on Tuesday morning.
The roads appeared to be dry and it was sunny at the time.
There are 5 people have been hurt, with police saying all injuries are considered non-life threatening.
Toronto Police called 4 ambulances to the scene.