Toronto police have identified the male who was shot downtown overnight as 36-year-old Rala Federick of Toronto.
Federick was rushed to hospital with serious injuries. He died of his injuries around 5 a.m., police said.
The shooting happened on George Street between Gerrard Street East and Dundas Street East around 2 a.m.
Federick was shot in the stomach, while another male was shot in the wrist, a Toronto EMS spokesperson told CP24.
The victim with the wrist wound was treated in hospital, but has since been released.
George Street has been shut down between Gerrard and Dundas streets as police investigate the fatal shooting.
Police are looking for one suspect who is described as a black male with a light complexion of about 20 to 30 years of age, standing about five-foot-ten with a heavy build.